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The next step would be ruling out the compressive etiologies by gadolinium-enhanced MRI and, after structural abnormality investigation, cerebrospinal fluid (CSF) analysis for inflammation and defining demyelinating extension

For patients dealing with significant thinning, you need physical restoration treatments: injected PRP, exosomes, or microneedling combined with exosomes

If the calculation is correct, consider splitting the dose

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Targeting IL-1, IL-22, and chemokine pathways Despite evidence that IL-1 significantly contributes to the progression of ALD in experimental models, clinical trials using IL-1 receptor antagonists [253] (anakinra, NCT01809132) and monoclonal antibodies [254] (canakinumab, NCT03775109) for severe AH have not demonstrated positive outcomes