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Moreover, the better internalization of 2 NP compared to that of 1 NF was further confirmed by the percentage of PPIX-positive and GFP-positive cells in fluorescence-activated cell sorting (FACS) analysis ( 2 NP , 25.35% 2.35% and 1 NF , 4.35% 0.11%

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the mevalonate pathway, which leads to the production of the antioxidant coenzyme Q10 that is essential for the function of the ferroptosis suppressor protein FSP1 26,27