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doi: 10.1007/s11064-018-2517-8 193 ProfaciC

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For instance, the use of phenytoin sodium alone can cause gastrointestinal irritation, and its long-term use can cause gingival hyperplasia, nervous system dysfunction, and hematopoietic system disorders

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Cycling off periodically may help maintain sensitivity and response

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Anti-angiogenesis agents: The natural ally of ICI Main anti-angiogenesis agents Solid tumors tend to secret multiple pro-angiogenetic factors such as VEGF (also known as VEGF-A), hepatocyte growth factor, and platelet derived growth factor

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