melanotic macule.

melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in A flat and oval-shaped melanotic

Name: melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in A flat and oval-shaped melanotic
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A flat and oval shaped melanotic macule on the vermilion border of the Download Scientific Diagram Oral Melanotic Macule: Symptoms and Treatment Skinsight Case of melanotic macule in a 46 F Let's review ORAL MELANOTIC MACULE FOCAL MELANOSIS . The oral melanotic macule is a flat, brown, mucosal discoloration produced by a focal increase in melanin Labial melanotic macule Labial melanotic macule (brown spot on lip) (Stony Brook Case 1) dermatology dermatopathology YouTube

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Description

Comparative Antioxidant Profiles Property Glutathione (GSH) Ergothioneine (EGT) Redox activity Very high, dynamic Moderate, stable Chemical stability Low (constantly recycled) Very high Specific transporter No Yes (OCTN1/SLC22A4) Tissue accumulation Limited High (brain, liver, eyes) Mitochondrial protection Indirect (via GPx) Direct DNA protection Mitochondrial (primary) Nuclear and mitochondrial Intestinal degradation Partial Very low Human synthesis Yes (liver) No (dietary only) Mushrooms as the Only Known Source of Both Molecules While glutathione is also found in other foods asparagus, avocado, red meat ergothioneine is found almost exclusively in mushrooms

However, these effects are secondary

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The STAT3/HIF-1/fascin-1 axis plays an important role in the hypoxic microenvironment of RA synovium, facilitating endothelial-to-mesenchymal transition (EndoMT) of FLS and thereby promoting migration and invasion (133)