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Similarly, with excellent mitochondrial targeting ability, SS-20 peptide modification is a promising strategy for mitochondria-targeted drug delivery systems (184)

10.1161/CIRCRESAHA.107.149724 103

ALA, as described before, can raise glutathione intracellularly, and it has a protective effect on ischemia-reperfusion injury in a variety of clinical conditions, such as simultaneous kidney-pancreas transplantation, 273 human liver transplantation, 274 and liver resection

3.4 Precision-orchestrated therapeutic architectures for uremic toxin neutralization A constellation of pharmacological interventions orchestrates colonic uremic toxin metabolism through exquisitely distinct mechanistic pathways: the synergistic convergence of folic acid and methylcobalamin administration catalyzes homocysteine metabolic recalibration, systematically attenuating serum asymmetric dimethylarginine (ADMA) concentrationsa formidable mediator of endothelial dysfunction and cardiovascular pathophysiology (Angelini et al., 2021

Stryer, 1988)