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In addition, selenated polysaccharides derived from diverse polysaccharide sources demonstrate distinct regulatory impacts on the gut microbiota of diabetic mice, potentially attributable to the differing effects of the polysaccharides themselves

As a selenoprotein, GPX4 is the main catalytic enzyme that mediates PLOOH reduction and detoxification in mammalian cells

Furthermore, we synthesize current therapeutic strategies targeting ferroptosis inhibition in AD, highlighting recent advances that hold significant implications for guiding present and future translational efforts

European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), European Association for the Study of Obesity (EASO)

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