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The gastric cancer tumor microenvironment is shaped by coordinated immune evasion, where tumor cells recruit suppressive populations (TAMs, MDSCs, and Tregs) and dampen effector T-cell and NK-cell function through checkpoint signaling, soluble mediators, and metabolic inhibitory circuits such as adenosine (155159) ( Supplementary Table 1 )

Ultimately, personalized nutritional strategies-incorporating genetic background, trace element status, and gut microbiota composition-represent a promising direction for the precise prevention and management of AITD ( Figure 1 )

Author contributions SAC: Writing review & editing, Conceptualization, Validation, Writing original draft, Supervision, Data curation

TRICARE works for substance abuse treatment much like a traditional health insurance plan, but it is specifically designed to support military members, veterans, and their families with both addiction recovery and mental health care

Due to the continuous exposure to occlusal forces and periodontal microorganisms, alveolar bone possesses a unique immune microenvironment distinct from the long bones, with more frequent interactions between monocytes/macrophages and MSCs (Sima et al., 2019)