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Although many clinical trials suggested that patients with MetS have more propensity for ED, it is difficult for these cross-sectional studies or meta-analysis to elucidate how MetS induce ED

Upon activation, Nrf2 translocates to the nucleus, binds specifically to the Antioxidant Response Element (ARE) and induces transcription of downstream genes (Baird and Dinkova-Kostova, 2011) (Figure 2B)

Blood 130(10):12091212 Choi R, Lee MN, Kim K, Baek SY, Kim TJ, Hong SN et al (2020) Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohns disease