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The NAD+ as a cofactor is crucial for the tricarboxylic acid cycle, mitochondrial oxidative phosphorylation, and glycolysis-related enzymatic reactions, and the levels of NAD+ in the cell are critical for neuronal survival (Liu et al., 2008)

160 (3), 487 e1e7

doi: 10.1016/B9780-44453480-4.000011 56 MalikRAAndag-SilvaADejthevapornCHakimMKohJSPinzonRet al

This signaling pathway is also vulnerable to the effects of oxidative stress

Theres also early laboratory research exploring additional areas, but that should not be treated as proof of clinical benefit in pets (Wakshlag JJ, 2010)