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doi: 10.1038/s41392-020-00297-2 92 JiangXStockwellBRConradM

Similarly, in diabetic ApoE-deficient mice, PKC has been demonstrated to contribute to the acceleration of atherosclerosis by modulating the IL-18/IL-18BP axis and MAP kinase signaling pathways, thereby promoting VCAM-1 expression, enhancing macrophage adhesion, impairing endothelial function, and amplifying inflammatory responses in both the aorta and macrophages [58, 59]