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Biochemically, the depletion of intracellular GSH and the inactivation of GPX4 lead to cell ferroptosis (Maiorino et al., 2018)

Phlebotomy is recommended in all those who are homozygous for C282Y and have elevated serum ferritin levels

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

Near the N-terminus of the sequence, two additional disulfides which form a nested pair, are the CSDs present in the structure of human ERO1 (Figure 4B)