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TIMBER Articles published in Th Page 187 and 188: Updated : 31/03/2010 RING BINDER IN Page 189 and 190: Updated : 31/03/2010 b Monstrosi Page 191 and 192: Updated : 31/03/2010 93

Mechanisms of Action (Proposed) Promotes nitric oxide synthesis and activates pathways involved in tissue repair and angiogenesis268

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The lyophilized form is relatively stable, but heat and humidity are its enemies

Amylin/Calcitonin Receptor Agonism (cagrilintide) Delays gastric emptying, reduces postprandial glucagon, and strongly promotes satiety Modulates appetite-regulating centers in the hindbrain, hypothalamus, and brain reward circuits, directly influencing food intake and choice May transiently activate the renin-angiotensin-aldosterone system with dose escalation, but without blood pressure or electrolyte derangements GLP-1 Receptor Agonism (semaglutide) Stimulates glucose-dependent insulin secretion and suppresses glucagon release to improve glycemic control Reduces appetite and ad libitum energy intake, with central effects on GLP-1R-expressing nuclei in hypothalamus and brainstem Delays gastric emptying and increases satiety, contributing to progressive bodyweight loss Pharmacokinetic Profile Route of Administration Subcutaneous Dosing Frequency Once weekly Route of Administration : Subcutaneous Injection Dosing Frequency: Once weekly Half -life: Cagrilintide: 7-8 days