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One report showed that the activity of NAD(P)H oxidase was increased in the retina of diabetic rats and that this might be involved in the development of diabetic retinopathy [27]

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Rather than targeting vascular tissues, PT-141 acts centrally in the brain through activation of melanocortin receptors located in the medial preoptic area (mPOA) of the hypothalamus, a critical region for regulating sexual behavior

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