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Advanced glycation end products accelerate rat vascular calcification through RAGE/oxidative stress

Figure 5 6.1.3 Regulating gut microbiota, inflammation, and metabolic syndrome through vitamin D receptor signalling The Vitamin D/VDR signaling pathway serves as a critical integrative axis for immune modulation, metabolic homeostasis, and gut microbiota composition

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52 Furthermore, the 5-Fluorouracil/protocatechuic acid synergy exerts anti-proliferative/pro-apoptotic effects and suppresses colony formation in AGS cells via P53 activation and Bcl-2 inhibition, demonstrating dual clinical advantages: reduced 5-Fluorouracil dosing requirements and enhanced apoptosis pathway targeting