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Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism

Topp MS, van Meerten T, Houot R, Minnema MC, Bouabdallah K, Lugtenburg PJ, et al

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World Journal of Nutrition and Health 6(1):1122

This is energetically costly, as the synthesis of each molecule of argininosuccinate requires hydrolysis of adenosine triphosphate (ATP) to adenosine monophosphate (AMP)