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Furthermore, isolated MSCs undergo an age-dependent functional decline in stemness and undergo intrinsic alterations during in vitro culture, which also reduces their functions [9, 10]

Proteins were then enzymatically digested, and the generated peptides were analysed by LCMS/MS analysis

Science and Reports, 7 (1), 3299

doi: 10.1038/nrd.2016.246 31 MatsuiHSopkoNAHannanJLBivalacquaTJ

Growth hormone secretagogues and bone Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are well-established mediators of bone growth and remodeling