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Transcriptomic analysis of unstimulated mouse CD8 + T cells, or ex vivostimulated mouse CD8 + T cells that were either left untreated (non-arrested), arrested in the cell cycle using hydroxyurea (HU), or released from HU-induced arrest (released) ( n =4)

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Nevertheless, relative glutamatergic excess appears to be specific to early stages of illness [8], and relates to more severe symptoms at presentation [17], as well as gray matter decline [19], cognitive [20], and functional [16, 17] impairments