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This protein stabilizes the fundamental components of translocation complexes when organized into oligomeric structures (41)

Immunoblot of indicated proteins in HeLa cells treated with Erastin (5 M) or indicated doses of RSL-3, an inhibitor of glutathione peroxidase 4 (GPX4) for 24 hours

Moreover, xCT is also expressed in the normal colon, but it was demonstrated that its overexpression in colorectal tumors is associated with the activation of MELK oncogene and Pi3K and RAS pathways, being xCT pharmacological blockade a way of affecting cancer cells tumorigenesis (111)

M., & Neumiller, J

In this study, IR780 was utilized as both a PTA and PS to generate ROS and induce a temperature increase under 808-nm laser irradiation