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168 Studies in experimental models have shown an association between AATD and oxidative stress

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ROS initiates increase of P2X7 expression on the mitochondrial membrane and activity of Complex I, hence increasing mitochondrial polarization, which leads to an elevation of a cascade of unfavorable processes: depolarization of the mitochondrial membrane, calcium overload, and release of cytochrome c , which ultimately leads to cell death by apoptosis way

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observed that recombinant Treponema pallidum protein regulates the ROS/NF-B pathway through ER stress