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Coffee enemas carry significant health risks including rectal perforation, severe electrolyte disturbances that can cause cardiac arrhythmias, caffeine toxicity, dehydration, thermal burns, and serious infections

Access to resources that offer a holistic understanding of SPIGFD is particularly important for patients and their families, providing the tools to understand the complexities of SPIGFD and emphasize the importance of early diagnosis and treatment adherence

Topical biglycan application in a murine model of Ehlers-Danlos syndrome

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