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Gastric acid production naturally increases during overnight fasting periods, making conditions like GERD and gastritis more likely to cause pain upon waking when the stomach is most acidic

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References Choi IY et al

Additionally, the presence of a competitive probiotic in the nasopharynx may also provide additional inhibition of pathogen colonisation, or prevent strain replacement through interference for host cell binding sites ( 6 Conclusion The growing prevalence of resistance to first- and second-line antibiotics, in the absence of an effective preventative strategy necessitates the need for alternative therapies that can reduce the enormous disease burden associated with NTHi infections

Acknowledgements We thank Kevin Huang, Jonathan Moore, and members of our laboratory for critical reading of the manuscript and constructive suggestions