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Heparin-polynitroxides: synthesis and preliminary evaluation as cardiovascular EPR/MR imaging probes and extracellular space-targeted antioxidants

10 mg Vial Most-cited dilution: 5 mL for 2 mg/mL yielding 5 doses per vial at 100 units each

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The classic approach to address this issue by a medicinal chemist is often to use a prodrug approach by connecting a brain targeting ligand to a drug molecule to form a prodrug and the drug is released after the prodrug enters the brain

Additionally, overproduction of proinflammatory cytokines impair the intestinal barrier and induce the accumulation and activation of immune cells, which drive further immune responses and sustain chronic intestinal inflammation in IBD (48, 49)