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Gettler LT, Ryan CP, Eisenberg DTA, Rzhetskaya M, Hayes MG, Feranil AB, et al

Recommended dosing of 1-2 mg subcutaneous injection 2-3x per week (6 mg/week total) compares to toxic dose estimated at ~22,500 mg (approximately 3,750 times higher than weekly dose)

Clinical trial data from Retatrutide research and from comparable GLP-1 compound trials consistently shows that participants maintaining 80g+ of protein daily preserved lean mass significantly better than those whose protein intake dropped under caloric suppression

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Both signaling pathways are key regulators of inflammation and pro-inflammatory responses, which are considered targets for developing anti-inflammatory therapeutic agents [23-26]