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Thus, modulating chaperone activity by increasing the chaperone concentration in the lens is one important strategy to interfere with protein aggregation in the lens

10.1371/journal.pone.0043967 47 KoJ

The notification requires the manufacturer to disclose a plethora of information including the dose, the conditions for use, the history of the use of the ingredient, published articles/citations and/or other evidence that leads the manufacturer to conclude that the product containing the non-GRAS ingredient is reasonably expected to be safe to use