FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate
Younossi 1,2,3 , Reem Al Shabeeb 4 , Katherine Elizabeth Eberly 4 , Dipam Shah 4 , Veronica Nguyen 1 , Janus Ong 5 , Saleh A Alqahtani 6 , Linda Henry 1,4,7 and Maria Stepanova 7 , (1)Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, (2)Center for Liver Disease, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, (3)Inova Medicine, Inova Health System, Falls Church, VA, (4)Inova Health Systems Medicine Service Line, Falls Church, VA, (5)College of Medicine, University of the Philippines, Manila, Philippines, (6)Johns Hopkins University School of Medicine, (7)Center for Outcomes Research in Liver Diseases, Washington, DC Background: High prevalence of obesity in the U.S
An ex vivo study using human skin fibroblasts demonstrates that hydroxocobaslamin penetrates intracellularly to form cyanocabalamin
No system is one dimensional and no system functions independently
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