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Contrary to the R -gene mediated HR-type cell death, recognition in the case of basal resistance is unspecific, as intruders are recognized based on their common molecular patterns

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Overexpression of anti-apoptotic proteins of the BCL-2 family, such as BCL-2, BCL-xL and MCL-1, is frequently found in various cancers, including AML, thereby perturbing homeostasis of survival pathways and protecting cancer cells from death 8

Laboratory workup ruled out major thyroid dysfunction and adrenal insufficiency