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These authors have found lower levels of this adipokine in obese patients with type 2 diabetes mellitus

Oral tolerance: therapeutic implications for autoimmune diseases

PMID: 28052884

Removal of breast cancer cells from extracellular matrix (ECM) and local invasion and migration initiation: Disruption of the connection of the cell to ECM through cellular adhesion proteins such as integrins, resulting in the dissociation of cancer cells from adjacent cells and the basement membrane, describes how metastasis begins (118)