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S., Chandraratna, R

NF-B signaling can be triggered by Toll-like receptors (TLRs), whereas monosodium urate (MSU) crystals, which act as a typical damage-associated molecular pattern (DAMP), can activate TLRs/NF-B [24]

Sikiric, P., Seiwerth, S., Rucman, R., Drmic, D., Stupnisek, M., Kokot, A.,

In ALD, Nrf2 deficiency enhances lipogenesis by promoting SREBP-1c activity, while also increasing -oxidation

Moreover, CF airway inflammation is due to an excessive neutrophil recruitment, triggered by extrinsic and intrinsic factors, and by an imbalance between reduced concentrations of anti-inflammatory molecules (IL-10, lipoxins, chemotaxis inhibitors, and neutrophil activators) and higher levels of pro-inflammatory proteins (calprotectin)