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The close associations of relatively abundant Stearic acid, Amiloride, and 3,4-Dimethoxyphenylethylamine with the identified OTUs, including Escherichia marmotae , Enterobacter hormaechei , Shigella boydii , Citrobacter koseri , and Subdoligranulum var iabile notably separated h-CKD groups from healthy controls

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Eventually, two methemoglobin-reducing enzymes were isolated