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The pathogenesis and the pathophysiology of sepsis is very complicated and multifaceted: numerous biological mechanisms, such as infection, inflammation, oxidative stress, immune system dysregulation, blood coagulation, endothelium dysfunction, tissue damage, elevated cellular death and/or apoptosis are involved during sepsis at tissue, cellular and molecular levels causing a damaging systemic reaction [379]

J Clin Invest 114(1):514 Zhang Q, Kulczynska A, Webb DJ, Megson IL, Botting NP (2013) A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation

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A study by Pumberger et al investigated the value of DECT for detecting disc injuries in the context of thoracolumbar vertebrae fractures in 295 discs in 67 patients over 50 years of age and demonstrated a high sensitivity of 0.85 as well as an improved interrater agreement (Fleisss 0.51 versus 0.41) compared to the reference standard MRI [25]

This association remained significant in regression models adjusted for age, sex, and initial clinical severity [adjusted-OR = 0.014 (95%CI = 0.0010.810), p = 0.039]