acetaminophen toxicity glutathione depletion Clinically relevant therapeutic approaches against hepatotoxicity and acute liver failure Too much paracetamol = dangerous

Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Acetaminophen Toxicity: OPPOSITE EFFECTS OF TWO FORMS OF GLUTATHIONE PEROXIDASE ScienceDirect Comment FEVER for links to alternatives in post Lets go through some basics: Paracetamol reduces fever and pain by acting in the brain. The body breaks it down mostly in the liver Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect

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