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In one study, AOD-9604 was shown to decrease the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1), in rats with rheumatoid arthritis

44,45 Numerous target proteins, including histone and non-histone, have been shown to be modified by SIRTs, and participates in the regulation of multiple fundamental cellular functions including glucose, and lipid metabolism, mitochondrial biogenesis, DNA repair, oxidative stress, apoptosis, and inflammation

It is reported that these enzymes are induced, as a protective mechanism (detoxification), under conditions of oxidative stress

CS Johnston, CG Meyer, JC Srilakshmi

Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia