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This work is supported by the Army Research Laboratory and the Army Research Office (W911NF-23-1-0334, W911NF-22-2-0210, W911NF-22-2-0246, W911NF-18-1-0200), Army Contracting Command (W52P1J-21-9-3023), DTRA (HDTRA1-21-1-0038, HDTRA1-20-1-0004) the Department of Energy (DE-SC0023278, DE-NA0003525), the National Science Foundation (CBET - 1936789), the Gates Foundation (INV-038694), DARPA (W911NF-23-2-0039), and the National Institutes of Health (1U19AI142780-01)

At the whole-body level, CDO partitioning is probably most dependent on the levels of these enzymes within tissues that have high levels of CDO and hence can generate cysteinesulfinate, because most cysteinesulfinate is likely further metabolized within the tissue in which it is generated

The novel Bach1 inhibitor HPP971 uniquely activates Nrf2 and reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis

Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)