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Thiamine pyrophosphokinase deficiency causes a Leigh disease like phenotype in a sibling pair: identification through whole exome sequencing and management strategies

295(23): 1297300 Jayasinghe KSA, Roberts CJC, Read AE

Bush are on the scientific advisory board of Prana Biotechnology Ltd

Then, the INT1-Se undergoes two successive [2,3]-sigmatropic rearrangements 44,45,46,47,48,49 to generate the para -amination intermediate ( INT3-Se ), which may readily react with HBr and then rearomatize to the desired product 2a (for details see Supplementary Figs 411)

The 8013 hyperinvasive meningococcus strain remains trapped and survives in the mucus layer in Calu3 grown on ALI (Peters et al., 2024), suggesting the use of a transcellular route