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10.1016/j.taap.2013.03.008 22 Dashner-TitusE

O'Loghlen A, Prez-Morgado MI, Salinas M, Martn ME

The extended conformation of GSH in the MGST1 structure is more similar to what has been found in soluble glutathione binding proteins including GSTs 30

PIP3 also triggers membrane recruitment of phosphoinositide-dependent protein kinase 1 (PDK1) and mTORC2, which phosphorylate T308 (in the activation loop) and S473 (in the hydrophobic motif) of AKT, leading to full activation of AKT [31, 32]