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Masubuchi Y, Bourdi M, Reilly TP, Graf ML, George JW, Pohl LR

Folding the mitochondrial UPR into the integrated stress response

4.3 Antioxidants in chemotherapy 4.3.1 Impact on chemotherapy-induced lipid peroxidation One of the important treatments for cancer, which is commonly known as chemotherapy, causes severe oxidative stress on normal tissues, and there is increased lipid peroxidation [136]

The clonal evolution model suggests that cumulative genetic and epigenetic alterations drive tumor progression, whereas the cancer stem cell model posits that a subset of tumor-initiating cells sustains growth and therapeutic resistance

Antibacterial activity Bacterial infection with Helicobacter pylori is associated with a marked increase in the risk of peptic ulcer disease and gastric cancer (47)