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The indication for PPI use was documented in 6,326 encounters (58.2%) with GERD (n=5,127, 47.2%), gastric or duodenal ulcer (n-1,453, 13.4%), and multiple indications (n=1,627, 15.0%) as the most common indications

Beyond antioxidant defense, it boosts white blood cell activity to strengthen immune function, helps build collagen in skin, joints, bones, and blood vessels, and speeds tissue repair and wound healing

Leaf-sheath tissue of 1015 mm at the feeding site (crown tissue above the root-shoot junction) was cut out, insects removed and used for sample extraction for various analyses

Altered autophagosome processing triggers abnormal iron accumulation, activating the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome via the cyclic GMP-AMP synthase-stimulator of interferon genes (CGAS-STING1) pathway (an autophagy-related pathway), leading to oxidative stress and ferroptosis

The latter promotes a state of lower OS, which in super-agers has been associated with superior memory (Mapstone et al., 2017)