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It doesn't bypass the hypothalamic-pituitary axis

Neuroscience 21 BarronM.GriffithsP.TurnbullD.BatesD.NicholsP

10.1111/j.1471-4159.2005.03220.x 165 YokoboriS.ZhangZ.MoghiebA.MondelloS.GajavelliS.DietrichW

This targeted approach helps reduce inflammation and improve circulation, contributing to its anti-inflammatory effects

This has been shown to be mediated via the reduction in c-Myc, which regulates oncogenic miRNA biogenesis and consequently elevates p57 levels to stimulate apoptosis and diminish colon cancer cell proliferation