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The 5xFAD transgenic mouse line has been genetically engineered to model features of AD through the expression of human amyloid precursor protein (APP) and presenilin-1 transgenes, which are associated with earlyonset AD [21]

[DOI] [PubMed] [Google Scholar] 13.Vukojevi J, Siroglavi M, Kanik K, Kralj T, Stani D, Kokot A, Kolari D, Drmi D, Sever AZ, Barii I, uran J, Boji D, Patrlj MH, Sjekavica I, Pavlov KH, Vidovi T, Vlaini J, Stupniek M, Seiwerth S, Sikiri P

Muscle Fatigue: Is It a Harmless Sign or a Silent Death Sentence Waiting to Strike

The majority of their expression can be found on a variety of innate immune cells, including mast cells, macrophages, and dendritic cells of the immune system (Nardo 2015

Within cells it is handled to the antioxidant Cu chaperone (ATOX1), which directs Cu + to Cu-transporting P-type ATPases (10,11)