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To date, anti-inflammatory drugs are the first-line treatment, according to the 2010 recommendations of the ASAS (71)

Perforin and granzymes have distinct roles in defensive immunity and immunopathology

They also aid in the prevention of gastrointestinal disorders such as bloating, constipation, and diarrhea

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EC 1.5.1.20), which catalyze important reactions in the conversion of homocysteine to methionine