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Moreover, peroxisomes, organelles involved in lipid metabolism, contain enzymes such as acyl-CoA oxidase that generate hydrogen peroxide as a by-product [61]

Similarly, in lung fibrosis, inhibition of the Nrf2 pathway is closely associated with elevated levels of oxidative stress in fibrotic tissues, which in turn triggers the abnormal deposition of fibrous components such as collagen, leading to a post-ferroptotic state in lung tissue cells [8, 9]

2007, pp

MDA was measured using the Thiobarbituric Acid Reactive Substances (TBARS) assay kit from Cayman Chemicals (Item No.10009055) following the manufacturers protocol

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