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found that plasma H 2 S levels were not changed in the MCT-induced PH of rats (Sirmagul et al., 2013)

A critical driver of AP pathogenesis was the dysregulated activation of the nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, a cytosolic multiprotein complex that orchestrates caspase-1-mediated maturation of pro-inflammatory cytokines interleukin-1 (IL-1) and IL-18, as well as gasdermin D (GSDMD)-dependent pyroptotic cell death (Ferrero-Andrs et al., 2020)

Nat Med 2018;24:107080

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