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Hepatocytes store excess copper using metallothioneins (MT1 and MT2) (Ge et al., 2022)

Mechanistically, EGCG co-treatment led to increased apoptosis and DNA damage compared to either agent alone, as evidenced by elevated levels of cleaved caspase-3 and PARP, a decrease in antiapoptotic Bcl-2, and an increase in pro-apoptotic Bad (60)

Long-term monitoring and follow-up of patients receiving iPSC-based treatments are also necessary to evaluate their safety and efficacy [507]

Mitchell et al.[6] measured the level of GSH depletion in the liver (of mice), and the amount of covalent binding of radiolabeled APAP metabolites (later identified as NAPQI) in the liver after a wide range of doses of APAP

The Journal of laboratory and clinical medicine, 133(6), 575582