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doi: 10.1038/s41586-018-0701-2 160 WinerDAWinerSShenLWadiaPPYanthaJPaltserGet al

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Serine from SSP can directly bind to pyruvate kinase M2 (PKM2), the last rate-limiting enzyme of glycolysis, and promote the allosteric activation of PKM2 for the positive feedback of continuously activated glycolysis and serine synthesis (Chaneton et al., 2012)

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