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The peptide received FDA approval in June 2019 under the brand name Vyleesi for treatment of acquired, generalized hypoactive sexual desire disorder in premenopausal women, establishing it as a first-in-class medication with a novel mechanism distinct from all previous sexual dysfunction treatments

In summary: While promising, these results are from animal models

LNCaP cells express a full length AR with a point mutation at position 877 (T877A), enabling the AR to be stimulated by different steroids (promiscuous AR) [39]

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