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The chemical didnt gain widespread use as a malaria treatment because it was no more effective than quinine, the standard therapy at the time

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Berland, MD, describes extracolonic findings as findings on CTC that have potential deleterious health effects and are asymptomatic, unsuspected, and unrelated to the colon

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This means there is a higher chance to have a baby with lower birth weight if the B12 intake is not enough during pregnancy, besides many other negative consequences