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Preterm-born individuals have been shown to have significantly lower forced expiratory volume in 1 s (FEV 1 ) than those born at term 11 , therefore providing a potential therapeutic window of opportunity for optimizing peak lung function, and highlights the importance of understanding the underlying mechanisms of PLD during childhood

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Interestingly, LDs actively participate in mammalian innate immunity by both cell-autonomously killing intracellular pathogens and locally, and by facilitating systemic metabolic adaptation to infection