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To test the radioprotective capacity of guanosine nucleotides, Asadullina et al

Administration less frequent than twice weekly likely allows complete dissipation of synaptic changes between doses, preventing the cumulative structural modifications that constitute Dihexas therapeutic mechanism

Thus, concern remains for higher on-target off-tumor toxicity with greater CAR-T cell expansion, as seen in a patient treated with ERBB2-CAR-T therapy who experienced fatal cytokine release syndrome from on-target, off-tumor effect [165]