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They can not only serve as representative readings of the functional output of microorganisms, but also may act as potential remote immune regulators in the intestinal-articular axis by affecting the energy metabolism and barrier balance of the intestinal epithelium, and regulating the activation threshold and cytokine network of immune cells (Wang G

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Thus, an increase in hepatic cholesterol levels leading to increased oxysterol production will activate LXR resulting in the increased expression of ABCG5 and ABCG8 facilitating the secretion of cholesterol in the bile