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The electron transport chain (ETC) constantly transfers electrons from NADH and FADH2 to oxygen while allowing protons (H + ) to pass through the inner mitochondrial membrane to form an electrochemical proton gradient that drives ATP synthesis

THE RELEVANCE OF NONSTANDARDISED IN VITRO NASAL CAST MODELS IN PRODUCT DEVELOPMENT Lucas Silva1 , Nathalie Hauchard2, Nuria Manzano1 & Gonalo Farias2 1Nanopharm Ltd, Franklin House, Grange Road, Cwmbran, NP44 3WY, UK 2Aptar Pharma, Route des Falaises, Le Vaudreuil, 27100, France Summary: More realistic in vitro tools are being explored to facilitate product development by providing a better link between in vitro studies and in vivo outcomes

When used at normal doses, they complement each other and are safe to combine

We included in the final review 17 papers, some of them measuring multiple environmental toxicants evaluated in unique study populations [19,29,30] (Figure 2)

For these analyses, a FASTA file of the E